11th Annual Meeting of Proteomics Society, India, 2019 and International Conference on Proteomics for System Integrated Bio-Omics, One Health and Food Safety
2nd- 4th Dec 2019,

Structural Proteomics and Drug Targets

In the previous times, the biomedical practice heavily relies on the external visible indicators for a particular physiological response but with the advent of next generation screening techniques it is now possible to identify measurable state of a biological component. The effective data driven and knowledge based high throughput techniques enables large data mining in the form of analyzed genes, proteins, metabolites that provides predictive signatures of cellular response. Additionally, integrating bioinformatics analysis along with system biology approaches offers an unprecedented opportunity to extract meaningful information in terms of molecular markers from complex dataset. The opportunistic discovery of novel biomarkers is urgently required to improve the clinical interventions as well as optimization of present conventional techniques that facilitates deployment of novel therapies.

Structural proteomics deals with the 3 dimensional structural orientations of the proteins with high biological interest in order to obtain the relationship between protein sequence, structure and function. With the newer technologies such as X-ray crystallography and nuclear magnetic resonance the structural biologists can now contemplate utilize these techniques to annotate structure and subsequent functions of the protein. The structure-activity relation can now be easily established for the uncharacterized proteins based solely on the structural homology with the known protein.

The drug target discovery revolves around DNA, RNA or a protein molecule that directly involved in the disease process and can become an excellent target for the development of new drug. The targets can be verified with the genomic and proteomic studies that can be further validated with the functional assays. It is also imperative to find a link between structural biology and functional aspect of a biomolecule in order to better validate structure based drug targeting approach.

Biological science is complex and rapidly changing and requires a specialized knowledge to understand the value of the innovation and its competitive position in the industry. Life science has the tremendous potential to offer a newer and less trodden path for the young minds that are not willing to continue their career as a great scientist. This inspires the nascent entrepreneurs to put their brilliant scientific acumen into the productive ventures. The existing technologies such as biotechnology, pharmacology, biochemistry and informatics can contribute to novel therapies, improved food quality, drug discoveries and other important interventions. To think strategically in life science ventures, it is important to find an enigmatic similarity based link between scientific and an entrepreneurial process.